Some properties of SF-973 B substance, the enzyme catalyzing the conversion of dihydroabikoviromycin to abikoviromycin.
نویسندگان
چکیده
Three components, SF-973 A, B, and C were obtained from a Streptomyces olivaceus SF-973. SF-973 B catalyzed the converison of inactive SF-973 C (dihydroabikoviromycin) to bioactive SF-973 A (abikoviromycin). Purification of SF-973 B was conducted by sequential chromatographies on columns of DEAE-cellulose, Sephadex G-75, and Sephadex G-100. The enzyme SF-973 B was most active at around pH 7 and 40~45°C in temperature range. The molecular weight was about 36,000. SF-973 B showed oxidoreductase activity and was named dihydroabikoviromycin dehydrogenase.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 26 3 شماره
صفحات -
تاریخ انتشار 1973